Employing solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests consist of:

Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination purpose.

[Laughs] ‘It had been absolutely a terrific chance! At time, I was nicely aware that it could go wrong Which I could develop into a lot less productive, but I just dismissed that. Curiosity has always been my strongest driving drive. And by chance all of it worked out.’

Our function was rapidly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors created from single- and multi-walled carbon nanotubes in Applied Physics Letters.

This yielded a breakthrough. Within just only a few months, we were being capable of evaluate transport as a result of a person one-walled carbon nanotube. Depending on small-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being genuine quantum wires with incredibly lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.

Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en met 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.

We use nanofabricated microfluidic constructions to pattern spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental job of spatial confinement at the molecular and cellular amount. Our jobs involve the subsequent:

He also identified time to jot down numerous guides, deliver Just about forty thousand tweets and lead An cees dekker effective investigate group at Delft University of Technological know-how. ‘It doesn’t truly feel like do the job’, he says. ‘I’m just terribly curious.’

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Dekker started off his investigation on single carbon nanotubes in 1993 when he setup a new line of exploration to study electrical transportation by means of one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was accomplished inside of a collaboration Together with the group of Nobel laureate Richard Smalley. STM and nanolithography approaches had been utilized to show that these nanotubes are quantum wires at The one-molecule degree, with superb physical Attributes.

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A lot of new phenomena had been found out, and he and his investigation group recognized a leading situation Within this industry of investigation. Dekker and his study team uncovered new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor depending on only one nanotube molecule.

2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational variations in Mre11/DNA fix complexes; and initially force measurements over a DNA molecule inside of a nanopore

Solid-state nanopores have proven to become a astonishingly flexible probe for single-molecule Evaluation of DNA. I will explain many of our the latest conclusions – specially DNA knots – together with our attempts to broaden the capabilities of good-point out nanopores even even further, from the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.